Crespine Gel – an injection for quiescence in the joint

Crespine Gel treatment is merely a single injection for osteoarthritis therapy.

Osteoarthritis therapy with Crespine Gel

The aims of a therapy with Crespine Gel are:

  • To maintain the healthy condition of the joint cartilage tissue as long as possible
  • Time-saving effect for the patient with only one appointment for the treatment
  • A single injection intervention enhances security for the patient
  • The regenerating of pain-relieved joint tissue functioning


Previously, patients often had to attend the medical practice 3 to 5 times at weekly intervals to receive the injections. With Crespine Gel, the treatment for the patient is now more comfortable and saves time. The effect of stabilized hyaluronic acid only requires a single injection in order to effect quiescence in the affected joint.


Stabilization also leads to a Gel, which can be injected through thin needles due to intelligent product properties. For patients, this means that a long-term effect can be achieved with only a minimal invasive intervention. The high degree of product stability in Crespine Gel enables just 2 ml of the substance to be applied very efficiently for each joint. A practically unnoticeable volume of Crespine Gel will effect long-term quiescence in the joint.

The Crespine Gel injection has two versions:

Crespine Gel +

Contents of Crespine Gel +:
1 ml CRESPINE GEL +  contains:
Hyaluronic acid                                  1,0 mg
Hyaluronic acid, cross linked        14,0 mg
sodium chloride                                  6,9 mg
Water for injection purposes            1,0 ml
Prilocainhydrochloride                      3,0 mg

German Pharmacy Central Number

Crespine Gel +: 08509246

Prilocaine serves as a local anesthetic to make the injection more tolerable.

The combination of hyaluronic acid and prilocain is unique and protected.

Crespine Gel

Contents of Crespine Gel:
1 ml CRESPINE GEL contains:
Hyaluronic acid                                     1,0 mg
Hyaluronic acid,  cross linked           14,0 mg
Natriumchloride                                    6,9 mg
Water for injection purposes               1,0 ml

German Pharmacy Central Number

Crespine Gel: 08509223

Application of Crespine Gel

Crespine Gel is injected by an experienced medical practitioner directly into the joint-line interstices.

Thus the stabilized hyaluronic acid arrives directly in the joint-line where the pain has its origin. The gel covers the cartilage protectively in order to prevent further degeneration by abrasion. Movement will be a pleasure again thanks to the quiescence in the joint tissue.

Healthy joint


Treated joint

The single injection should be repeated at regular intervals. In the early stages (degree I to II), the effect can last as long as around 9 months. Some patients also report longer successful intervals.

An early stage medical clarification of joint pain can help in benefiting from the Crespine Gel effect for a more pleasant lifespan with an original natural joint.

Safety and time-saving result from a Crespine Gel injection


A single injection is sufficient for one treatment cycle, and our patients benefit from enhanced safety and time-saving.

Instead of having to show up in the practice on several appointments only one appointment is sufficient. Instead of having to put up with 3-5 injections into the joint-line, , one single injection of Crespine Gel is sufficient. Sterile conditions in the practice ensure enhanced security for patients.


Medical experts agree, that patients give feedback of long time periods of quiescence experienced in their joints due to the stabilized (cross-linked) hyaluronic acid. The cross-linking of hyaluronic acid is a well-established process for the stabilization of the molecules. Experienced medical practitioners know how to carry out the treatment so that the patients experience a satisfying therapy success.

7 Facts about Crespine Gel

  • The essential active ingredient in Crespine Gel is highly pure stabilized hyaluronic acid. Hyaluronic acid is an essential component in the natural healthy joint-lubricating fluid. This protects the joint and the cartilage by its property of being able to bind water and spread itself over the cartilage as a lubricant protectively. This lubricating effect is lost in presence of osteoarthritios as well as in inflammatory conditions in the joint tissue as a result of a lack of natural hyaluronic acid. The application of Crespine Gel is thus meaningful in the majority of cases.
  • Crespine Gel possesses a very high degree of purity due tof its special manufacturing process as well a very high degree of stability. Crespine Gel is injected as a gel implant. It can be applied very easily under pressure through a needle and once inserted into the joint Crespine Gel readopts its original gel consistency.
  • Crespine Gel can help in retaining the original natural joint over long periods of time in many cases.
  • The hyaluronic acid in Crespine Gel is from biofermentation origin and is therefore very well tolerable..
  • The cross-linking of the hyaluronic acid in Crespine Gel produces a viscous gel and this istays in the joint tissue for a longer period of time. Cross-linked hyaluronic acid is very well tolerated when the joint tissue at the moment of the treatment is free from any inflammation and the patient enjoys a good physical condition.
  • The natural ‘shock-absorbing’ effect of the joint tissue fluids is best promoted by the Crespine Gel implant.
  • Crespine Gel is a high-quality product, which is entirely produced in Germany (of ‘Made in Germany’ Quality).


Crespine Gel is medical product and thus available without prescription. You will find Crespine Gel in our online shop. Should the your medical practitioner not have Crespine Gel in the practice, you can easily order it from netHEAVEN GmbH (Inc.) and take it to the appointment. A needle is not included in the package because the medical practitioner should select this for the purpose as required in each individual case.

Patients should observe the storage instructions: dry and cool between 2⁰C and 25⁰C).

Crespine Gel has a best-before-date of up to 3 years after manufacture. Patients can easily contact netHEAVEN GmbH (Inc.) to obtain such information. The corporation will reply promptly.

Crespine Gel needs to be injected by an experienced and specialized medical practitioner. Only such experts can provide the patient with personalized information and as to whether hyaluronic acid treatment represents a successful therapy option in each individual case. Such a medical practitioner can also advise the patient regarding necessary medical clarifications in advance.

If you are suffering from osteoarthritis and become more active again after treatment, then we have achieved our aim.